We study the topological and structural properties of the bank–sector credit network of Spain over the period 1997–2007. In particular, we start by analyzing assortativity, different types of motifs and the nestedness phenomenon, both in the bipartite structure of the binary version of the network and in its weighted version. In order to assess the statistical significance of the network properties, we employ the family of the so-called bipartite configuration models, imposing initial constraints such as the degree sequence and/or strength sequence of the observed bipartite network. We find that, in the binary version, the so-called bipartite binary configuration model, maintaining the observed degrees, can replicate the main features of many properties of the observed network. In addition, the one-mode projection matrixes, which indicate lending portfolio overlaps between banks and borrowing portfolio overlaps between sectors, can mostly be predicted by information embedded in the degree sequence of the original bipartite structure. In the weighted version, we observe that the so-called bipartite enhanced configuration model, where both the degree and the strength sequences are preserved, outperforms (on average) the so-called bipartite weighted configuration model, which maintains only the strength sequence in replicating the topological features of the network. Moreover, comparing the observed network to all the referenced null models, we still find a number of features of higher-order topological properties that cannot be explained by information embedded in the observed degree and/or strength sequence. In particular, we discover an “excessive” weighted clustering of the banks and sectors with the highest degrees.